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Aberdeen research team say the drug trodusquemine reduces levels of cholesterol in mice and humans. Trodusquemine, a spermine metabolite of cholesterol, is a naturally occurring aminosterol that inhibits protein tyrosine phosphatase 1b Administration of trodusquemine in a mouse model of breast cancer inhibited her2 signaling, xenograft growth and lung metastasis [131]. This prevents the dephosphorylation of the insulin receptor, which improves insulin signaling and insulin sensitivity, and decreases blood glucose levels.
Trodusquemine suppresses feeding, prevents reduction in energy expenditure, causes hormonal changes, and induces patterns of neuropeptide expression normally associated with weight loss.
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