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This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. The encoded protein is believed to be an integral membrane protein involved in small molecule transport, specifically tyrosine, which is a precursor to melanin synthesis. This gene encodes a member of the cytochrome p450 superfamily of enzymes The cytochrome p450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.
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